Inotiv, Inc. (NOTV), a provider of drug discovery and development services in the Healthcare sector, demonstrates permissible core business activities focused on medical diagnostics and research. However, severe financial imbalances, including a debt ratio of 618.26% of market capitalization and an interest income ratio of 11.08%, result in non-compliance across all major Shariah screening standards. The company is excluded from all key Shariah indices due to these metrics, despite a compliant liquidity position and no non-permissible revenue sources. Purification of 11.08% is required for any dividends, and ESG factors show medium risk with minor resolved controversies. Overall, NOTV is not suitable for Shariah-compliant portfolios without significant financial restructuring.