MSOX, an ETF tracking the US cannabis sector, fails Shariah compliance primarily due to involvement in haram activities related to intoxicants. Financial ratios cannot be assessed due to insufficient ETF data, but business activity screening disqualifies it across standards. No inclusion in major Shariah indices confirms non-compliance. ESG factors reveal moderate to high risks in environmental and social areas, with ongoing controversies. Investors should avoid or seek purification, though core haram nature limits viability.